I have a 2013 wrangler rubicon unlimited with a 3.5 AEV lift. I like the handling with 25 psi. Is that too low for highway driving? Will it cause excess tread wear?
25 is absolutely safe for the tires. As I've pointed out many times, a 35" x 12.5" tire is rated to carry 1875 pounds per tire at 25 PSI. Your Jeep weighs much less than 1875*4 or 7500 pounds.
How low tire pressure affects handling is a more complex question. It can make sharp turns less crisp, or affect how load shifts from side to side in sudden maneuvers. We really can't give you guidance there.
I run that on my 35 12.50's Trxus MT. Only issues I have experienced is I do get a vibration at highway speeds that comes and goes, believe it's the sidewalls flexing and developing a harmonic.
I am running balancing beads in them so may not have the correct weight in them due to some blowing out seating the rim.
Calculations put my Goodyear Wrangler Duratrac E-rated 35s at 30psi and they ride great on highway at that pressure. Off-road they are bone rattling at 30psi.
I've run several sets of 305/65-17 BFG KO2's @ 28psi on my JKU's...usually replace them around 60k miles. Currently running 28psi on 305/70-17 KO3's on my JLU, and so far, so good. Off road (beach or trail) I drop them to 18psi, and they do great....