I have a lift, but only 35" tires. I just returned from a 1700 mile round trip while flat towing. I have the following setup:
Blue Ox tow bar
Maximus3 tow loops, and Blue Ox adapters
Cooltech wiring harness
Rvi3 brake.
The large tires shouldn't matter. But, if it's got modified suspension (lift), make sure you have checked the caster to ensure at least the factory caster angle. Caster is why a flat towed vehicle follows the tow vehicle.